Looking at the list of all others that could be included, having Desire there, which I don't think would be much of a crowd pleaser, takes time away from the chance of their being a new song. Makes me worry it will just be old stuff.
There are plenty of things to have meltdowns about. Desire being chosen for a 45 minute show is not one of them. I think it's a crowd pleaser; the audience can sing-a-long to some stuff and Bono on harmonica always gets some cheers. U2 plays it a lot, in any situation, whether it's 3 or 23 songs.