Going to be bold here with my predictions -
For the most part, I think the opener will stay the same. However, I think U2 will switch in a different opener for cities who have two shows. My guess is that will be the spot and few times that we'll see Stand Up Comedy. I'm kind of torn on the song, but the people I know who aren't die hards like me, love that song, and casual fans outnumber the die hards.
I do think the closer will not so much be rotated out, but on some shows we'll see something after Moment of Surrender. Perhaps White as Snow or Cedars of Lebanon. At these shows, a song will be dropped from the new album - perhaps Unknown Caller and maybe Crazy Tonight once. It's a single, I'd be surprised if it was regularly dropped.
Now for the non-NLOTH songs:
The nightly regulars in Europe won't change much. If anything, I see Walk On and MLK being rotated more with Europe rarities such as Angel of Harlem and Bad.
New Year's Day, Elevation, Until the End of the World and Mysterious Ways will start to be played more as well, as sad to say it, but Unforgettable Fire and Ultraviolet will gradually be played less and less.
The rarities that will be play on the US leg will be: Your Blue Room (2 shows), HMTMKMKM (3 shows), Drowning Man (for 1 show), Hands That Built America (snippet - 4 shows), I Will Follow (3 shows), New York (played only in New York), Gone (Large cities only), and as a very very special treat to Chicago Night 2 - The Fly.
to see that sequence.
