Only one mention of Bugs Bunny? Come on! No contest. He's like the Groucho Marx of the cartoon world. Obnoxious, subversive, anarchistic. And fucking hilarious.
Hottest cartoon female (my own subtopic) is a tie between Judy Jetson and Trixie from Speed Racer.
warner brothers original stuff took the cake - bugs, elmer, daffy, that era.
some of the best and most well thought out ever... did you know "What's Opera Doc" is studied in universities because of its similarities to German Expressionism
Sylvester, Tweety, Wylie E Coyote, Road Runner...
Add to that, Tom and Jerry, Micky Mouse & co... All better IMO than current cartoons.
Probably Daffy Duck if I had to pick.