I'll be in the minority and say I'd like to see them move away from Eno/Lanois. Yes, they helped them expand their sound on UF and JT, and the reinventions on AB and ATYCLB and they maybe squeezed a great album out of U2 with NLOTH but if they're serious about the 12 year old deal of touring/recording they will need another reinvention IMO and I don't see it happening with those two.
I was always hoping Rubin could get something great out of them, like he did with other artists in the late stage of their career (Diamond, Cash, Petty, Metallica). Or maybe Nigel Godrich would be a good idea. I liked his remix of Walk on and anyone that can do this - According to interviews, the idea of bringing in a younger producer was for McCartney to challenge himself, and accordingly Godrich fired McCartney's touring band on the first day's sessions, and demanded the star abandon songs Godrich felt to be clichéd, over-sentimental or subpar - can bring U2 to the top of their game too.