Toughest loss for me would be losing the '05 national championship game. If that team wasn't destined to win a championship, I don't know who was. And then...poof. Didn't happen. Still an amazing run that I'll never forget. Starting out the season 29-0 by playing some of the most beautiful, team-oriented basketball I've ever seen. The comeback against Arizona, etc.
Sigh.
I glazed over national championship game for whatever reason, and thought you were talking about the White Sox until the very end of that post and was incredibly confused.