I'd take an acoustic Mofo over most of the current set.
As for changes, well, I think there will only be significant changes if there is a new album. A new album would probably necessitate a new opening sequence, not to mention a couple of songs mid-set being discarded in favour of a new song (a rotational mid-set slot and IALW?).
If there is no new album, I don't see much in the way of changes. Maybe they'll realise that Stingray/IWF/BDay would flow much better than Stingray/BDay/IWF. I expect MOTD to replace Scarlet in Chile and at least one Argentinian show. The set, much as I may criticise it, seems to have become settled. I could only see them shaking up the order a bit if they do add a final run through Europe, to give a different experience to 2010 (but maybe not, if they mainly go to European markets skipped in 2010, like the UK).