Yep. They're the closest thing to ye olde U2 going. In a way, you could say that Coldplay could pull off an All That You Can't Leave Behind, and Muse could pull off a superficially spectacular 360 type stadium show, but Arcade Fire are the ones that are actually in the position to pull off a Joshua Tree. And you mention their artful/coherent records - they come with artful/coherent creative extensions, so I'd say they're the ones best poised to pull off a creatively all encompassing ZooTV type extension.
Before the peanut gallery jumps on that, that's not a direct comparison - Arcade Fire will likely never go as direct/wide appeal as U2 did during that period, and thus not as universally huge, but of all the bands mentioned in here, Arcade Fire are the ones who are right now, in many, many ways (but in their own way), sitting right about where U2 were circa UF. Watch what happens if Arcade Fire's next album is universally agreed upon as near perfect, and on top of that has just one or two songs that are just a bit more direct/wide appeal, and so to some degree truly cross over. And that's certainly not inconceivable, and they're certainly not a band without ambition.
Muse, Coldplay, Kings of Leon, Snow Patrol, Killers (or whoever else in that 'A' grade of size these days) have peaked or are peaking, and in terms of all of career arc, creativity and performance are all in varying ways only very, very, very, very, very, very superficially comparable to where U2 were at or headed. They're all pretenders, comparably. To make the comparisons, you're either missing the essence, or you're only looking at U2's career arc, creativity and performance in very, very, very superficial ways.