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Old 03-26-2007, 12:18 PM   #1
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Scientists create sheep that's 15% human

On the one hand this is really fascinating but on the other it's really worrisome, at least to me, as to how far science will go.

Isn't this messing with the natural order of things?

http://www.mailonsunday.co.uk/pages/...0&in_a_source=



Quote:
Now scientists create a sheep that's 15% human

By CLAUDIA JOSEPH

Scientists have created the world's first human-sheep chimera - which has the body of a sheep and half-human organs.

The sheep have 15 per cent human cells and 85 per cent animal cells - and their evolution brings the prospect of animal organs being transplanted into humans one step closer.

Professor Esmail Zanjani, of the University of Nevada, has spent seven years and £5million perfecting the technique, which involves injecting adult human cells into a sheep's foetus.

Chimera: sheep have 15 per cent human cells and 85 per cent animal cells

He has already created a sheep liver which has a large proportion of human cells and eventually hopes to precisely match a sheep to a transplant patient, using their own stem cells to create their own flock of sheep.

The process would involve extracting stem cells from the donor's bone marrow and injecting them into the peritoneum of a sheep's foetus. When the lamb is born, two months later, it would have a liver, heart, lungs and brain that are partly human and available for transplant.

"We would take a couple of ounces of bone marrow cells from the patient,' said Prof Zanjani, whose work is highlighted in a Channel 4 programme tomorrow.

"We would isolate the stem cells from them, inject them into the peritoneum of these animals and then these cells would get distributed throughout the metabolic system into the circulatory system of all the organs in the body. The two ounces of stem cell or bone marrow cell we get would provide enough stem cells to do about ten foetuses. So you don't just have one organ for transplant purposes, you have many available in case the first one fails."

At present 7,168 patients are waiting for an organ transplant in Britain alone, and two thirds of them are expected to die before an organ becomes available.

Scientists at King's College, London, and the North East Stem Cell Institute in Newcastle have now applied to the HFEA, the Government's fertility watchdog, for permission to start work on the chimeras.

But the development is likely to revive criticisms about scientists playing God, with the possibility of silent viruses, which are harmless in animals, being introduced into the human race.

Dr Patrick Dixon, an international lecturer on biological trends, warned: "Many silent viruses could create a biological nightmare in humans. Mutant animal viruses are a real threat, as we have seen with HIV."

Animal rights activists fear that if the cells get mixed together, they could end up with cellular fusion, creating a hybrid which would have the features and characteristics of both man and sheep. But Prof Zanjani said: "Transplanting the cells into foetal sheep at this early stage does not result in fusion at all."
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Old 03-26-2007, 12:23 PM   #2
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Quote:
Now scientists create a sheep that's 15% human

That's nothing, the GOP have been creating human's that are more than 50% sheep for decades.
























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Old 03-26-2007, 12:30 PM   #3
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Quote:
Originally posted by BonoVoxSupastar



That's nothing, the GOP have been creating human's that are more than 50% sheep for decades.
























LOL What do you call Democrats???
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Old 03-26-2007, 12:35 PM   #4
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Iexpected the first joke in th thread to be about the part of the sheep's anatomy that most closely resembles a human's and causes sheep to be nervous all over Vermont.
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Old 03-26-2007, 05:01 PM   #5
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Quote:
Originally posted by BonoVoxSupastar



That's nothing, the GOP have been creating human's that are more than 50% sheep for decades.
























Damn BVS, that was the first thing I thought when I saw this thread
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Old 03-26-2007, 05:16 PM   #6
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I'd hit it.
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Old 03-26-2007, 05:17 PM   #7
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Quote:
Originally posted by BonoVoxSupastar



That's nothing, the GOP have been creating human's that are more than 50% sheep for decades.


And I'm not even a Democrat (nor a republican.)
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Old 03-26-2007, 07:27 PM   #8
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I was hoping she would be better looking.
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Old 03-26-2007, 08:25 PM   #9
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Quote:
Originally posted by Hewson
Iexpected the first joke in th thread to be about the part of the sheep's anatomy that most closely resembles a human's and causes sheep to be nervous all over Vermont.
I thought the sheep were most nervous in West Virginia...at least that's what the Ohioans & Pennsylvanians I know tell me.
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Old 03-27-2007, 12:52 AM   #10
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Old 03-27-2007, 01:01 AM   #11
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In news just to hand, twenty female human-sheep just boarded a flight to Auckland, New Zealand.

Lonely Kiwi farmers are reportedly over the moon with delight.
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Old 03-27-2007, 01:03 AM   #12
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I'd like to know more about it. In terms of cells, it's not that foreign to transplant or mirror the structure of one species to another, I'd thought. I don't know much, with the exception of insulin being the one I do know of, having used porcine insulin for the last 22 years. Maybe that makes me 0.5% pig?
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Old 03-27-2007, 07:20 AM   #13
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It would just be the insulin that is pig, none of your body's cells would contain any of the genetic makeup of a pig...insulin is only a protein, which varies slightly between animals...technically fish insulin would work in humans as well...

The benefits of this research is that they could grow exact copies of your organs in the sheep, no need for immunosuppressants as the markers on the surface of cells which determine whether it is 'self' (belongs to your body) or foreign (something that shouldn't be there), the markers will be the exact same as your own body's, hence the immune system will not try and reject the organ.
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Old 03-27-2007, 12:53 PM   #14
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Most people don't know this, but I'm 15 percent sheep.
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Old 03-27-2007, 01:47 PM   #15
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And the rest?
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