Guy: Do you have any Irish in you?
Girl: Um, no.
Guy: Well, do you want some?
And this isn't a pick-up line but it's kinda related and a goodie:
Q: What's a blonde's mating call?
A: "OMG I'm soooooo drunk!"
Q: What's an ugly blonde's mating call?
A: I *SAID*, I'm SO DRUNK!"