It all depends what we mean by 'space', doesn't it guys? If we're talking about the local neighbourhood, well we do pretty much know what is there already. If we're talking much further afield, well that's a whole other matter. I guess I'll wait until the engineering problems are overcome.
I love it when people say there's no aliens. Not because I necessarily think they are a dime a dozen the way they in are programs like Doctor Who or Star Trek, but because our sights are awfully limited at this point. We just don't know. We need to consider the possibility of other life forms that are below us in development. What if we are the first?
Now how would we go about detecting an intelligent civilisation on, fuck I don't know, one of those planetary systems they're picking up in recent years... but one which was at a sort of ancient-Egypt stage. They're hardly going to be generating much noise.