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Old 08-24-2010, 07:32 PM   #1
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Parts of Protein Stop HIV in Monkeys

It's been more than 25 years since scientists discovered HIV, the retrovirus responsible for causing AIDS. Since then, there have been advances in treatment that help slow the spread of the virus, promising leads toward stopping it entirely, but still no cure. Now, out of Loyola University, a potential breakthrough: Researchers have figured out the "key components" of TRIM5-alpha, a natural protein that "gangs up" and destroys the virus in rhesus monkeys.

"The finding could lead to new TRIM5a-based treatments that would knock out HIV in humans," senior researcher Edward M. Campbell, PhD, of Loyola University Health System said in a press release.

The results of the research are described in full in the Sept. 15 issue of Virology and have also been posted online. (Subscription required.) Six years ago, researchers at Harvard first identified the protective power of TRIM5a in monkeys, noting that it is 87 percent identical to a variant of the protein found in humans.


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Old 08-24-2010, 08:43 PM   #2
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*Fingers crossed*



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Old 08-26-2010, 10:01 AM   #3
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"By continuing to narrow their search, researchers hope to identify an amino acid, or combination of amino acids, that enable TRIM5a to destroy HIV. Once these critical amino acids are identified, it might be possible to genetically engineer TRIM5a to make it more effective in humans.
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